Progress of Selenium Deficiency in the Pathogenesis of Arthropathies and Selenium Supplement for Their Treatment.

Huan Deng, Haobiao Liu, Zhihao Yang, Miaoye Bao, Xue Lin, Jing Han, Chengjuan Qu

Journal: Biological trace element research 2022;200(10):4238-4249

PMID: 34779998

Abstract

Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.

Address: School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, People's Republic of China.; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, People's Republic of China. [email protected].; Department of Odontology, Umeå University, 90187, Umeå, Sweden.

DOI: 10.1007/s12011-021-03022-4

Link outs

Free resources

Medical:

https://medlineplus.gov/osteoarthritis.html

Subscription / membership required

Full Text Sources:

https://dx.doi.org/10.1007/s12011-021-03022-4

MeSH Terms: Cartilage, Humans, Kashin-Beck Disease, Osteoarthritis, Oxidative Stress, Selenium