Targeting Ca signaling: A new arsenal against cancer.

Suman Panda, Oishika Chatterjee, Laboni Roy, Subhrangsu Chatterjee

Journal: Drug discovery today 2022;27(3):923-934

PMID: 34793973

Full Text on Elsevier Science View on PubMed

Abstract

The drug resistance of cancer cells is a major concern in medical oncology, resulting in the failure of chemotherapy. Ca plays a pivotal role in inducing multidrug resistance in cancer cells. Calcium signaling is a critical regulator of many cancer hallmarks, such as angiogenesis, invasiveness, and migration. In this review, we describe the involvement of Ca signaling and associated proteins in cancer progression and in the development of multidrug resistance in cancer cells. We also highlight the possibilities and challenges of targeting the Ca channels, transporters, and pumps involved in Ca signaling in cancer cells through structure-based drug design. This work will open a new therapeutic window to be used against cancer in upcoming years.

Address: Department of Biophysics, Bose Institute, P-1/12 CIT Road, Scheme VIIM, Kankurgachi, Kolkata 700054, India.; Department of Biophysics, Bose Institute, P-1/12 CIT Road, Scheme VIIM, Kankurgachi, Kolkata 700054, India. Electronic address: [email protected].

DOI: 10.1016/j.drudis.2021.11.012

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1359...

MeSH Terms: Calcium, Calcium Signaling, Drug Resistance, Multiple, Humans, Neoplasms