Physical Activity and Sedentary Behavior in Adults With Cystic Fibrosis: Association With Aerobic Capacity, Lung Function, Sleep, Well-Being, and Quality of Life.

Máire Curran, Audrey C Tierney, Brenda Button, Louise Collins, Lauren Kennedy, Ciara McDonnell, Ali Sheikhi, Andrew Jurascheck, Brian Casserly, Roisin Cahalan

Journal: Respiratory care 2022;67(3):339-346

PMID: 34815328

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Abstract

BACKGROUND

Physical activity (PA) and sedentary behavior (SB) have marked impact on key prognostic indicators such as aerobic capacity and lung function in people with cystic fibrosis (CF) and may have associations with sleep, well-being, and health-related quality of life (HRQOL).

METHODS

This observational study assessed PA, SB, aerobic capacity, spirometry, sleep, well-being, and HRQOL in adults with CF at University Hospital Limerick. PA and SB were assessed using an accelerometer that was worn for 7 days. A cardiopulmonary exercise test assessed aerobic capacity. Spirometry was performed according to American Thoracic Society guidelines. Well-being was measured by the AWESCORE, sleep quality by the Pittsburgh Sleep Quality Index (PSQI), and HRQOL using the CF Questionnaire-Revised.

RESULTS

Thirty-three participants (13 males/20 females) were recruited. Mean age was 26.2 y (± 7.1 SD), with mean FEV 72.9% of predicted (± 26.2 SD). Mean step count was 7,788 (± 3,583 SD). Over 75% of participants did not reach recommended PA targets (> 10,000 steps), with females being 25.5% less active than males. The PSQI indicated 48.5% of participants scored > 5, indicating poor sleep quality. Number of steps and SB demonstrated a moderate significant correlation with FEV (r = 0.45, = .030; r = -0.37, = .043, respectively) and sleep quality (r = -0.85, < .001; r = 0.77, < .001, respectively). [Formula: see text] peak expressed relative to body weight, and as a percentage of predicted, was significantly positively correlated with step count (r = 0.48, = .007; r = 0.42, = .02, respectively) but did not correlate with SB ( = .96). [Formula: see text] peak (L/min) strongly correlated with FEV (r = 0.75, < .001).

CONCLUSIONS

Most participants did not meet PA targets. PA levels correlated to aerobic capacity, FEV, and self-reported sleep quality, and this should be considered in longitudinal studies and in PA interventions.

Address: School of Allied Health, University of Limerick, Limerick, Ireland. [email protected].; University Hospital Limerick, Limerick, Ireland and Health Research Institute, University of Limerick, Limerick, Ireland.; School of Allied Health, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Limerick, Ireland; Health Implementation Science and Technology Research Group, Health Research Institute, University of Limerick, Limerick, Ireland and Department of Dietetics, Nutrition and Sport, La Trobe University, Melbourne, Australia.; Departments of Respiratory Medicine and Physiotherapy, The Alfred, Melbourne, Australia and Department of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.; University Hospital Limerick, Limerick, Ireland.; Health Research Institute, University of Limerick, Limerick, Ireland.; School of Allied Health, University of Limerick, Limerick, Ireland.; School of Allied Health, University of Limerick, Limerick, Ireland; and Health Research Institute, University of Limerick, Limerick, Ireland.

DOI: 10.4187/respcare.09270

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MeSH Terms: Adult, Cystic Fibrosis, Exercise, Female, Humans, Lung Volume Measurements, Male, Quality of Life, Sedentary Behavior, Sleep