Antiviral Therapeutic Potential of Curcumin: An Update.

Abdollah Ardebili, Mohammad Hassan Pouriayevali, Sahar Aleshikh, Marziyeh Zahani, Mehdi Ajorloo, Ahdieh Izanloo, Abolghasem Siyadatpanah, Hadi Razavi Nikoo, Polrat Wilairatana, Henrique Douglas Melo Coutinho

Journal: Molecules (Basel, Switzerland) 2021;26(22):6994

PMID: 34834089

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Abstract

The treatment of viral disease has become a medical challenge because of the increasing incidence and prevalence of human viral pathogens, as well as the lack of viable treatment alternatives, including plant-derived strategies. This review attempts to investigate the trends of research on in vitro antiviral effects of curcumin against different classes of human viral pathogens worldwide. Various electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar were searched for published English articles evaluating the anti-viral activity of curcumin. Data were then extracted and analyzed. The forty-three studies (published from 1993 to 2020) that were identified contain data for 24 different viruses. The 50% cytotoxic concentration (CC50), 50% effective/inhibitory concentration (EC50/IC50), and stimulation index (SI) parameters showed that curcumin had antiviral activity against viruses causing diseases in humans. Data presented in this review highlight the potential antiviral applications of curcumin and open new avenues for further experiments on the clinical applications of curcumin and its derivatives.

Address: Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.; Department of Arboviruses and Viral Hemorrhagic Fevers (National Ref Lab), Pasteur Institute of Iran, Tehran 1316943551, Iran.; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.; Student Research Committee, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.; Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran.; Department of Virology, Lorestan University of Medical Sciences, Khorramabad 6813833946, Iran.; Department of Biology, Faculty of Science, Golestan University, Gorgan 4934174515, Iran.; Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran.; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.; Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan 4934174515, Iran.; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.; Laboratory of Microbiology and Molecular Biology (LMBM), Regional University of Cariri (URCA), Crato 63105-000, CE, Brazil.

DOI: 10.3390/molecules26226994

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MeSH Terms: Antiviral Agents, Curcumin, Humans, Virus Diseases