Ionic channels in nerve membranes, 50 years on.

Bertil Hille

Journal: Progress in biophysics and molecular biology 2022;169-170():12-20

PMID: 34856230

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Abstract

This retrospective traces the hypothesis of ion channels from an early statement in a 1970 essay in this journal (Hille, B., 1970, Prog. Biophys. Mol. Biol. 21, 1-32) to its realization today in biophysical, molecular, biochemical, and structural terms. The Na and K channels of the action potential have been isolated, reconstituted, cloned, mutated, and expressed. They are conformationally flexible, multi-pass glycosylated membrane proteins. Refined atomic structures of several conformational states are known. The discoveries over this half century history illustrate the growth of a field from initial ideas to a mature discipline of biology, physiology, and biomedical science.

Address: Department of Physiology and Biophysics, University of Washington, School of Medicine, Box 357290, Seattle, WA, 98195-7290, USA. Electronic address: [email protected].

DOI: 10.1016/j.pbiomolbio.2021.11.003

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MeSH Terms: Ion Channels, Ions, Potassium, Retrospective Studies, Sodium