miRNA-148b and its role in various cancers.

Najmeh Dorraki, Zari Naderi Ghale-Noie, Nooshin Sadegh Ahmadi, Vahideh Keyvani, Rosita Azar Bahadori, Arash Salmani Nejad, Michael Aschner, Hossein Pourghadamyari, Samaneh Mollazadeh, Hamed Mirzaei

Journal: Epigenomics 2022;13(24):1939-1960

PMID: 34852637

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Abstract

miRNA-148b belongs to the family miR-148/-152, with significant differences in nonseed sequences, which can target diverse mRNA molecules. Reportedly, it may undergo deregulation in lung and ovarian cancers and downregulation in gastric, pancreatic and colon cancers. However, there is a need for further studies to better characterize its mechanism of action and in different types of cancer. In this review, we focus on the aberrant expression of miR-148b in different cancer types and highlight its main target genes and signaling pathways, as well as its pathophysiologic role and relevance to tumorigenesis in several types of cancer.

Address: Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Genetics, Faculty of Medicine, Tehran Medical Sciences Islamic Azad University, Tehran, Iran.; Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.; Department of Biology, Parand Branch, Islamic Azad University, Tehran, Iran.; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.; Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.; Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran.; Natural Products & Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.; Research Center for Biochemistry & Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.

DOI: 10.2217/epi-2021-0155

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https://www.tandfonline.com/doi/10.2217/epi-2021-0...

MeSH Terms: Apoptosis, Cell Proliferation, Down-Regulation, Humans, MicroRNAs, Neoplasms