Sex Bias in Differentiated Thyroid Cancer.

Valentine Suteau, Mathilde Munier, Claire Briet, Patrice Rodien

Journal: International journal of molecular sciences 2021;22(23):12992

PMID: 34884794

Abstract

Differentiated thyroid cancers are more frequent in women than in men. These different frequencies may depend on differences in patient's behavior and in thyroid investigations. However, an impact on sexual hormones is likely, although this has been insufficiently elucidated. Estrogens may increase the production of mutagenic molecules in the thyroid cell and favor the proliferation and invasion of tumoral cells by regulating both the thyrocyte enzymatic machinery and the inflammatory process associated with tumor growth. On the other hand, the worse prognosis of thyroid cancer associated with the male gender is poorly explained.

Address: Department of Endocrinology, Diabetology and Nutrition, University Hospital Angers, 49000 Angers, France.; MITOVASC Institute, University of Angers, 49100 Angers, France.; Centre de Référence des Maladies Rares de la Thyroïde et des Récepteurs Hormonaux, CHU Angers, 4 Rue Larrey, CEDEX 9, 49000 Angers, France.

DOI: 10.3390/ijms222312992

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https://medlineplus.gov/thyroidcancer.html

MeSH Terms: Estrogens, Female, Gonadal Steroid Hormones, Humans, Male, Prognosis, Receptors, Estrogen, Sex Factors, Sex Ratio, Thyroid Gland, Thyroid Neoplasms