Combinatorial, additive and dose-dependent drug-microbiome associations.

Address: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Charité-Universitätsmedizin Berlin, Berlin, Germany.; Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin and the Max-Delbrück Center, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin and the Max-Delbrück Center, Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany.; Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université, INSERM, Paris, France.; Nutrition Department, Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Paris, France.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Microbiology, VIB, and Rega Institute, KU Leuven, Leuven, Belgium.; Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université, INSERM, Paris, France.; Assistance Publique Hôpitaux de Paris, UF Biomarqueurs Inflammatoires et Métaboliques, Biochemistry and Hormonology Department, Tenon Hospital, Paris, France.; Centre de Recherche Saint-Antoine, Sorbonne Université, INSERM UMR S938, Paris, France.; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.; Charité-Universitätsmedizin Berlin, Berlin, Germany.; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, Gothenburg, Sweden.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.; MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, and MOE Frontiers Center for Brain Science, Shanghai, China.; Nutritional Epidemiology Research Team (EREN), Sorbonne Paris Cité Epidemiology and Statistics Research Centre (CRESS), U1153 INSERM, U1125, INRA, CNAM, University of Paris 13, Paris, France.; Metagenopolis, INRA, AgroParisTech, Université Paris-Saclay, Paris, France.; Cardiology Department, Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Paris, France.; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.; Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université, INSERM, Paris, France.; Integromics Unit, Institute of Cardiometabolism and Nutrition, Paris, France.; Sorbonne Université, IRD, Unité de Modélisation Mathématique et Informatique des Systèmes Complexes, UMMISCO, Paris, France.; Department of Pharmacology, Sorbonne Université, INSERM CIC-1901, UNICO-GRECO Cardio-oncology ProgramAP-HP.Sorbonne, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.; Department of Cardiology, Rigshopitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Rigshopitalet, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark.; Nutrition Department, Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Paris, France.; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; Biobyte Solutions, Heidelberg, Germany.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden.; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.; McGill University and Genome Quebec Innovation Centre, Montréal, Québec, Canada.; Section of Genomic and Environmental Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College London, London, UK.; European Genomic Institute for Diabetes, CNRS UMR 8199, INSERM UMR 1283, Institut Pasteur de Lille, Lille University Hospital, University of Lille, Lille, France.; Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université, INSERM, Paris, France. [email protected].; Nutrition Department, Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Paris, France. [email protected].; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany. [email protected].; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig, Leipzig, Germany. [email protected].; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. [email protected].; Charité-Universitätsmedizin Berlin, Berlin, Germany. [email protected].; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. [email protected].; Yonsei Frontier Lab (YFL), Yonsei University, Seoul, South Korea. [email protected].