Involvement of serine / threonine protein kinases in DNA damage response and cell division in bacteria.

Yogendra S Rajpurohit, Dhirendra Kumar Sharma, Hari S Misra

Journal: Research in microbiology 2022;173(1-2):103883

PMID: 34624492

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Abstract

The roles of Serine/Threonine protein kinases (STPKs) in bacterial physiology, including bacterial responses to nutritional stresses and under pathogenesis have been well documented. STPKs roles in bacterial cell cycle regulation and DNA damage response have not been much emphasized, possibly because the LexA/RecA type SOS response became the synonym to DNA damage response and cell cycle regulation in bacteria. This review summarizes current knowledge of STPKs genetics, domain organization, and their roles in DNA damage response and cell division regulation in bacteria.

Address: Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Life Sciences, Homi Bhabha National Institute (DAE- Deemed University), Mumbai, 400094, India. Electronic address: [email protected].; Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Life Sciences, Homi Bhabha National Institute (DAE- Deemed University), Mumbai, 400094, India.; Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, 400085, India; Life Sciences, Homi Bhabha National Institute (DAE- Deemed University), Mumbai, 400094, India. Electronic address: [email protected].

DOI: 10.1016/j.resmic.2021.103883

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MeSH Terms: Bacteria, Bacterial Proteins, Cell Division, DNA Damage, Protein Serine-Threonine Kinases, Serine, Threonine