Inflammaging and Cannabinoids.

Babak Baban, Hesam Khodadadi, Évila Lopes Salles, Vincenzo Costigliola, John C Morgan, David C Hess, Kumar Vaibhav, Krishnan M Dhandapani, Jack C Yu

Journal: Ageing research reviews 2022;72():101487

PMID: 34662745

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Abstract

Aging is a complex phenomenon associated with a wide spectrum of physical and physiological changes affecting every part of all metazoans, if they escape death prior to reaching maturity. Critical to survival, the immune system evolved as the principal component of response to injury and defense against pathogen invasions. Because how significantly immune system affects and is affected by aging, several neologisms now appear to encapsulate these reciprocal relationships, such as Immunosenescence. The central part of Immunosenescence is Inflammaging -a sustained, low-grade, sterile inflammation occurring after reaching reproductive prime. Once initiated, the impact of Inflammaging and its adverse effects determine the direction and magnitudes of further Inflammaging. In this article, we review the nature of this vicious cycle, we will propose that phytocannabinoids as immune regulators may possess the potential as effective adjunctive therapies to slow and, in certain cases, reverse the pathologic senescence to permit a more healthy aging.

Address: Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, DCG Center for Excellence in Research, Scholarship and Innovation (CERSI), Augusta University, Augusta, GA, USA; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta, Augusta University, Augusta, GA, USA; Department of Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA. Electronic address: [email protected].; Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia, DCG Center for Excellence in Research, Scholarship and Innovation (CERSI), Augusta University, Augusta, GA, USA; Center for Excellence in Research, Scholarship and Innovation, Dental College of Georgia, Augusta, Augusta University, Augusta, GA, USA.; European Medical Association (EMA), Brussels, Belgium.; Parkinson's Foundation Center of Excellence, Movement Disorders, Program, Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.; Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.; Department of Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA.

DOI: 10.1016/j.arr.2021.101487

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MeSH Terms: Aging, Cannabinoids, Humans, Immune System, Immunosenescence, Inflammation