The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER).
Tiia Ngandu, Jenni Lehtisalo, Saana Korkki, Alina Solomon, Nicola Coley, Riitta Antikainen, Lars Bäckman, Tuomo Hänninen, Jaana Lindström, Tiina Laatikainen, Teemu Paajanen, Satu Havulinna, Markku Peltonen, Anna Stigsdotter Neely, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
2022;18(7):1325-1334
PMID: 34668644
Abstract
INTRODUCTION
Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre-specified subgroup analyses).
METHODS
FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self-reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
RESULTS
Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
DISCUSSION
Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Address:
Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Department of Psychology, University of Cambridge, Cambridge, UK.; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.; Faculté de Médecine, INSERM-University of Toulouse UMR1295 (CERPOP), Toulouse, France.; Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France.; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.; Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Joint municipal authority for North Karelia social and health services (Siun sote), Joensuu, Finland.; Finnish Institute of Occupational Health, Helsinki, Finland.; Department of Public Health and Welfare, Functioning and Service Needs Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Social Psychological Sciences, Karlstad University, Karlstad, Sweden.; Engineering Psychology, Luleå University of Technology, Luleå, Sweden.; Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; South Ostrobothnia Central Hospital, Seinäjoki, Finland.; Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.; Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.; Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Stockholm, Sweden.; Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, UK.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.; Theme Aging, Karolinska University Hospital, Solna, Sweden.
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