Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview.

Fereshteh Nazari-Khanamiri, Morteza Ghasemnejad-Berenji

Journal: Journal of food biochemistry 2021;45(11):e13972

PMID: 34664285

Abstract

Genistein is the simplest secondary metabolite in soybeans and belongs to a group of compounds called isoflavones. It is a phytoestrogen and it makes up more than 60% of soy isoflavones. Studies have shown the anti-inflammatory, anti-apoptotic, and anti-angiogenic effects of genistein in addition to its modulatory effects on steroidal hormone receptors. In this review, we discuss the pharmacologic and therapeutic effects of genistein on various diseases. PRACTICAL APPLICATIONS: In this review, we have discussed the therapeutic effects of genistein as the main constituent of soybeans on health conditions. Its antioxidant, anti-inflammatory, anti-apoptotic and, anti-angiogenic effects need more attention. The pharmacological properties of genistein make this natural isoflavone a potential treatment for various diseases such as postmenopausal symptoms, cancer, bone, brain, and heart diseases. Special emphasis should be given to it, resulting in using it in clinical as a safe, potent, and bioactive molecule.

Address: Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.; Experimental and Applied Pharmaceutical Research Center, Urmia University of Medical Sciences, Urmia, Iran.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

DOI: 10.1111/jfbc.13972

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https://doi.org/10.1111/jfbc.13972

MeSH Terms: Antioxidants, Genistein, Isoflavones, Phytoestrogens, Glycine max