Structural elucidation of spiro cyclohexandienonyl naphthalenes with potential anti-neuroinflammatory activities from Caragana acanthophylla Kom.

Di Zhou, Tiantian Zhang, Qingbo Liu, Jingyu Liu, Yanqiu Yang, Bin Lin, Gang Chen, Yue Hou, Ning Li

Journal: Phytochemistry 2021;192():112976

PMID: 34678624

Full Text on Elsevier Science View on PubMed

Abstract

Four undescribed spiro cyclohexandienonyl naphthalenes (acanthophyllas A-D) and a revised compound were isolated from the roots of Caragana acanthophylla Kom. (Fabaceae). They were identified using extensive spectroscopic data and via chemical methods. Three of them were resolved into their enantiomers, and their absolute configurations were confirmed by comparing the experimental and calculated electronic circular dichroism spectra. Moreover, the anti-inflammatory activities of the compounds were investigated by evaluating their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 cells. Some compounds showed significant inhibitory activities with IC values of 8.8-13.4 μM (minocycline, IC 7.8 μM), indicating that they might serve as potential therapeutic agents for neurodegenerative diseases.

Address: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University; Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang, 110016, People's Republic of China.; College of Life and Health Sciences, Northeastern University, Shenyang, 110004, People's Republic of China.; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.; College of Life and Health Sciences, Northeastern University, Shenyang, 110004, People's Republic of China. Electronic address: [email protected].; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University; Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang, 110016, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2021.112976

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0031...

MeSH Terms: Anti-Inflammatory Agents, Caragana, Lipopolysaccharides, Molecular Structure, Naphthalenes, Nitric Oxide