Di(2-ethylhexyl) phthalate (DEHP) and thyroid: biological mechanisms of interference and possible clinical implications.

Xueting Zhang, Wen Qi, Qi Xu, Xu Li, Liting Zhou, Lin Ye

Journal: Environmental science and pollution research international 2022;29(2):1634-1644

PMID: 34677768

Abstract

Di(2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental endocrine disruptor. DEHP can be absorbed into the human body through the air, food, water, and skin. After entering the human body, DEHP is rapidly converted to mono(2-ethylhexyl) phthalate (MEHP) with greater toxicity than DEHP. An increasing number of studies indicates that DEHP or MEHP can damage the thyroid tissue and disrupt the function, but the mechanisms remain unclear. This article reviews the toxicity of DEHP on thyroid structures and functions and summarizes the potential mechanisms to provide evidence for preventing the thyroid-related diseases.

Address: Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021, China.; Department of Occupational and Environmental Health, School of Public Health, Jilin University, 1163 Xin Min Street, Changchun, 130021, China. [email protected].

DOI: 10.1007/s11356-021-17027-y

Link outs

Subscription / membership required

Full Text Sources:

https://dx.doi.org/10.1007/s11356-021-17027-y

MeSH Terms: Diethylhexyl Phthalate, Endocrine Disruptors, Humans, Phthalic Acids, Thyroid Gland