The basis of nuclear phospholipase C in cell proliferation.

Ca is a highly versatile intracellular signal that regulates many biological processes such as cell death and proliferation. Broad Ca-signaling machinery is used to assemble signaling systems with a precise spatial and temporal resolution to achieve this versatility. Ca-signaling components can be organized in different regions of the cell and local increases in Ca within the nucleus can regulate different cellular functions from the increases in cytosolic Ca. However, the mechanisms and pathways that promote localized increases in Ca levels in the nucleus are still under investigation. This review presents evidence that the nucleus has its own Ca stores and signaling machinery, which modulate processes such as cell proliferation and tumor growth. We focus on what is known about the functions of nuclear Phospholipase C (PLC) in the generation of nuclear Ca transients that are involved in cell proliferation.

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