Pancreatic paraganglioma diagnosed by endoscopic ultrasound-guided fine needle aspiration: A case report and review of literature.

Gandhi Lanke, John M Stewart, Jeffrey H Lee

Journal: World journal of gastroenterology 2021;27(37):6322-6331

PMID: 34712035

Free Full Text on Baishideng Publishing Group Inc. View on PubMed

Abstract

BACKGROUND

Pancreatic paragangliomas (PPGL) are rare benign neuroendocrine neoplasms but malignancy can occur. PPGL are often misdiagnosed as pancreatic neuroendocrine tumor or pancreatic adenocarcinoma.

CASE SUMMARY

We reviewed 47 case reports of PPGL published in PubMed to date. Fifteen patients (15/47) with PPGL underwent endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Only six (6/15) were correctly diagnosed as PPGL. All patients with PPGL underwent surgical resection except three (one patient surgery was aborted because of hypertensive crisis, two patients had metastasis or involvement of major vessels). Our patient remained on close surveillance as she was asymptomatic.

CONCLUSION

Accurate preoperative diagnosis of PPGL can be safely achieved by EUS-FNA with immunohistochemistry. Multidisciplinary team approach should be considered to bring the optimal results in the management of PPGL.

Address: Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Lubbock, TX 79407, United States.; Pathology-lab Medicine Division, MD Anderson Cancer Center, Houston, TX 77030, United States.; Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, TX 77030, United States. [email protected].

DOI: 10.3748/wjg.v27.i37.6322

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/pancreaticcancer.html

MeSH Terms: Adenocarcinoma, Endoscopic Ultrasound-Guided Fine Needle Aspiration, Female, Humans, Pancreas, Pancreatic Neoplasms, Paraganglioma