Iron disorders and hepcidin.

Shilpa Rana, Nirmal Prabhakar

Journal: Clinica chimica acta; international journal of clinical chemistry 2021;523():454-468

PMID: 34755647

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Abstract

Iron is an essential element due to its role in a wide variety of physiological processes. Iron homeostasis is crucial to prevent iron overload disorders as well as iron deficiency anemia. The liver synthesized peptide hormone hepcidin is a master regulator of systemic iron metabolism. Given its role in overall health, measurement of hepcidin can be used as a predictive marker in disease states. In addition, hepcidin-targeting drugs appear beneficial as therapeutic agents. This review emphasizes recent development on analytical techniques (immunochemical, mass spectrometry and biosensors) and therapeutic approaches (hepcidin agonists, stimulators and antagonists). These insights highlight hepcidin as a potential biomarker as well as an aid in the development of new drugs for iron disorders.

Address: Department of Biochemistry, Sector-25, Panjab University, Chandigarh 160014, India.; Department of Biochemistry, Sector-25, Panjab University, Chandigarh 160014, India. Electronic address: [email protected].

DOI: 10.1016/j.cca.2021.10.032

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MeSH Terms: Anemia, Iron-Deficiency, Hepcidins, Homeostasis, Humans, Iron, Iron Deficiencies