Targeting Wnt/β-catenin signaling by microRNAs as a therapeutic approach in chemoresistant osteosarcoma.

Foroogh Hosseini, Forough Alemi, Faezeh Malakoti, Ata Mahmoodpoor, Simin Younesi, Bahman Yousefi, Zatollah Asemi

Journal: Biochemical pharmacology 2022;193():114758

PMID: 34481813

Full Text on Elsevier Science View on PubMed

Abstract

Osteosarcoma (OS) is an adolescent and young adult malignancy that mostly occurs in long bones. The treatment of OS is still a big challenge for clinicians due to increasing chemoresistance, and many efforts are being made today to find more beneficial treatments. In this regard, the use of microRNAs has shown a high capacity to develop promising therapies. By targeting cancer-involved signaling pathways, microRNAs reduce the cellular level of these protein pathways; thereby reducing the growth and invasion of tumors, and even leading cancer cells to apoptosis. One of these oncogenic pathways that play an important role in OS development and can be targeted by microRNAs is the Wnt/β-catenin signaling pathway. Hence, the first goal of this review article is to explain the cross-talk of microRNAs and the Wnt/β-catenin signaling in OS and then discussing recent findings of the use of microRNAs as a therapeutic approach in OS.

Address: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Anesthesiology Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Anesthesiology and Intensive Care, School of Medicine, Tabriz University of Medical Science and Health Services, Tabriz, Iran; Anesthesiology Research Team, Tabriz University of Medical Sciences, Tabriz, Iran.; Schoole of Health and Biomedical Sciences, RMIT University, Melborne, VIC, Australia.; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected].; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: [email protected].

DOI: 10.1016/j.bcp.2021.114758

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MeSH Terms: Bone Neoplasms, Drug Resistance, Neoplasm, Humans, MicroRNAs, Osteosarcoma, Wnt Proteins, beta Catenin