Tracking temporal response dynamics in the ventral striatum during social feedback in anorexia nervosa: A functional magnetic resonance imaging exploratory study.

Sonia Membrives, Marina López-Solà, Fernando Fernández-Aranda, Isabel Sánchez, Ignacio Martínez-Zalacaín, Diego Palao, Jesus Pujol, Jose M Menchón, Chris G Davey, Ben J Harrison, Charlotte Keating, Susan L Rossell, Joan C Oliva, Carles Soriano-Mas, Narcís Cardoner, Esther Via

Journal: The International journal of eating disorders 2021;54(10):1881-1886

PMID: 34487358

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Abstract

OBJECTIVE

Research suggests abnormalities in reward-based processes in anorexia nervosa (AN). However, few studies have explored if such alterations might be associated with different temporal activation patterns. This study aims to characterize alterations in time-dependent processes in the ventral striatum (VS) during social feedback in AN using functional magnetic resonance imaging (fMRI).

METHOD

Twenty women with restrictive-subtype AN and 20 age-matched healthy controls (HC) underwent a social judgment experimental fMRI task. Temporal VS hemodynamic responses were extracted in SPM for each participant and each social condition (acceptance/rejection).

RESULTS

Compared with age-matched HC, patients with AN showed a significant time by group interaction of peak VS response throughout the task, with a progressive blunting of peak activation responses, accompanied by a progressive increase in baseline activity levels over time.

DISCUSSION

The results suggest an attenuated response pattern to repetitive social rejection in the VS in patients with AN, together with a difficulty in returning to baseline. The information obtained from this study will guide future, design-specific studies to further explore alterations temporal dynamics.

Address: Department of Mental Health, Parc Taulí-University Hospital of Sabadell, Sabadell, Spain.; Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona, Barcelona, Spain.; Mental Health Networking Biomedical Research Centre (CIBERSAM), Barcelona, Spain.; Serra Hunter Programme, Department of Medicine, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Bellvitge University Hospital, Institut d'Investigació Biomèdica de Bellvitge IDIBELL, Barcelona, Spain.; Carlos III Health Institute, Obesity and Nutrition Biomedical Research Centre (CIBEROBN), Barcelona, Spain.; Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Mental Health Networking Biomedical Research Centre (CIBERSAM), Barcelona, Spain.; MRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain.; Mental Health Networking Biomedical Research Centre (CIBERSAM), Barcelona, Spain.; Bellvitge University Hospital, Institut d'Investigació Biomèdica de Bellvitge IDIBELL, Barcelona, Spain.; Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.; Centre for Mental Health, Faculty of Health Sciences, Art and Design, Swinburne University of Technology, Melbourne, Australia.; Mental Health Networking Biomedical Research Centre (CIBERSAM), Barcelona, Spain.; Bellvitge University Hospital, Institut d'Investigació Biomèdica de Bellvitge IDIBELL, Barcelona, Spain.; Department of Psychobiology and Methodology in Health Sciences, Universitat Autónoma de Barcelona, Barcelona, Spain.; Child and Adolescent Psychiatry and Psychology Department of Hospital Sant Joan de Déu of Barcelona and Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

DOI: 10.1002/eat.23604

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MeSH Terms: Anorexia Nervosa, Feedback, Female, Humans, Magnetic Resonance Imaging, Reward, Ventral Striatum