When Supramolecular Chemistry Meets Chemical Biology: New Strategies to Target Proteins through Host-Guest Interactions.

Wenbing Cao, Xuewen Qin, Tao Liu

Journal: Chembiochem : a European journal of chemical biology 2022;22(20):2914-2917

PMID: 34487417

Abstract

Supramolecular chemistry for targeting proteins is of great interest for the development of novel approaches to recognize, isolate and control proteins. Taking advantage of chemical biology approaches, such as genetic-code expansion and enzyme-mediated ligation, guest recognition elements can be built into proteins of interest, allowing supramolecular control of protein function and regulation. In this viewpoint article, we will discuss the methods, applications, limitations, and future perspectives of supramolecular chemistry for targeting proteins in a site-specific manner.

Address: State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Haidian District, Beijing, 100191, P. R. China.; College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, 94 Weijin Road, Nankai District, Tianjin, 300071, P. R. China.

DOI: 10.1002/cbic.202100357

Link outs

Subscription / membership required

Full Text Sources:

https://doi.org/10.1002/cbic.202100357

MeSH Terms: Macromolecular Substances, Molecular Structure, Proteins