Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?

Zisong Wei, Hua Chai, Yan Chen, Yue Cheng, Xiaojing Liu

Journal: Current opinion in pharmacology 2021;60():291-297

PMID: 34507029

Full Text on Elsevier Science View on PubMed

Abstract

Nicotinamide adenine dinucleotide (NAD) is essential for cellular physiological processes, directly or indirectly affecting metabolism and gene expression. The decline of NAD levels in the heart is accompanied by aging, causing cardiac pathological remodeling and dysfunction. Niacinamide mononucleotide (NMN) has emerged as a precursor to alleviate age-related cardiac pathophysiological changes by improving cardiac NAD homeostasis. Preclinical trials on the efficacy and safety of intaking NMN have shown encouraging results, revealing a cardioprotective effect without significant side effects. Strategies for improving the effectiveness of NMN are also evolving. The present review aimed to summarize the potentials of NMN as a nutraceutical against cardiac aging and highlight the relationship between NMN supplementation and cardiac protection.

Address: Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China.; Department of Academic Affairs, West China School of Medicine, Sichuan University, Chengdu, 610041, China.; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China.; Laboratory of Cardiovascular Diseases, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: [email protected].

DOI: 10.1016/j.coph.2021.08.006

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MeSH Terms: Aging, Dietary Supplements, Humans, NAD, Niacinamide, Nicotinamide Mononucleotide