Human periodontal ligament stem cells and hormesis: Enhancing cell renewal and cell differentiation.

Edward J Calabrese

Journal: Pharmacological research 2022;173():105914

PMID: 34563662

Full Text on Elsevier Science View on PubMed

Abstract

This paper provides a detailed assessment of hormetic dose responses by human periodontal ligament stem cells (hPDLSCs). Hormetic dose responses were induced by a broad range of chemicals, including dietary supplements (e.g., curcumin, ginsenoside Rg1), pharmaceutical/commercial substances (e.g., metformin) and endogenous agents (e.g., periostin, TNF-α) for cell proliferation/viability and osteogenic/adipocyte differentiation. This paper clarifies underlying mechanistic foundations of the hPLDSC hormetic dose responses and explores their therapeutic implications. Emerging evidence based on assessments of multiple types of stem cells shows hormetic dose responses to be widespread, reflecting considerable generality and a highly conserved evolutionary trait.

Address: School of Public Health and Health Sciences, Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, Unites States. Electronic address: [email protected].

DOI: 10.1016/j.phrs.2021.105914

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MeSH Terms: Cell Differentiation, Cell Proliferation, Hormesis, Humans, Periodontal Ligament, Stem Cells