Melatonin in neuroskeletal biology.

Anish Patel, Edward W Zhou, Morgan O'Brien, Xin Wang, Shuanhu Zhou

Journal: Current opinion in pharmacology 2021;61():42-48

PMID: 34607253

Full Text on Elsevier Science View on PubMed

Abstract

Osteoporosis and neurodegenerative diseases are common diseases in the aging population. Studies demonstrate the complex communication among skeletal, muscular, and nervous systems and point to the emerging roles of neuromuscular systems in bone homeostasis. The discovery that the nervous system directly regulates bone remodeling implies that osteoporosis is a neuroskeletal disease. Melatonin, a hormone secreted from the pineal gland, is a melatonin receptor 1A (MT1) and 1B (MT2) agonist and influences the function of diverse systems. Melatonin is a pharmaceutical ingredient in numerous medicines, over-the-counter medicines, nutraceuticals, and dietary supplements, which benefit disease prevention and treatment, including osteoporosis and neurodegenerative diseases. This review aims to summarize the recent advances in preventing senile, postmenopausal, and neurodegenerative osteoporosis with melatonin and provide new insights into how neuromuscular systems influence bone homeostasis. More preclinical and clinical studies in neuroskeletal biology will eventually improve the lives of people fighting osteoporosis.

Address: Skeletal Biology Laboratory, Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Neuroapoptosis Drug Discovery Laboratory, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Neuroapoptosis Drug Discovery Laboratory, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].; Skeletal Biology Laboratory, Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address: [email protected].

DOI: 10.1016/j.coph.2021.08.016

Link outs

Free resources

Medical:

https://medlineplus.gov/osteoporosis.html

Subscription / membership required

Full Text Sources:

MeSH Terms: Aged, Biology, Humans, Melatonin, Osteoporosis, Receptor, Melatonin, MT1, Receptor, Melatonin, MT2