The effect of sumac (Rhus coriaria L.) supplementation on glycemic indices: A systematic review and meta-analysis of controlled clinical trials.

Mohsen Mohit, Mehran Nouri, Mehnoosh Samadi, Yasaman Nouri, Neda Heidarzadeh-Esfahani, Kamesh Venkatakrishnan, Cyrus Jalili

Journal: Complementary therapies in medicine 2021;61():102766

PMID: 34365008

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Abstract

BACKGROUND & AIMS

Rhus coriaria L. (Sumac) is a popular spice/herb with several biological functions owing to its antioxidant and insulin-like activities. Many clinical trials have indicated the potent anti-diabetic property of sumac but the results on few glycemic indices were inconclusive. Hence, this systematic review and meta-analysis were aimed to investigate sumac supplementation effect on glycemic indices.

METHODS

Systematically searched was performed by two independent reviewers using online databases including: PubMed, Scopus, web of science, EMBASE from inception until November 2020. Data were pooled using a random-effects model and weighted mean difference (WMD) with 95 % confidence intervals (CI).

RESULTS

A total of 6 potentially relevant clinical trials met the inclusion criteria with total of 278 participants. Random-effects meta-analysis suggested no significant effects on the levels of fasting blood glucose [-7.08 mg/dl, 95 % CI: -14.85 to 0.70,P = 0.07, I = 59.8 %], glycosylated hemoglobin (HbA1c) [-0.48 %, 95 % CI: -1.01 to -0.04, P = 0.07, I = 0.0 %], homeostatic model assessment for insulin resistance (HOMA-IR) [-0.97, 95 % CI: -1.96 to 0.02, P = 0.05, I = 83.8 %], and insulin [-2.94 Hedges' g, 95 % CI: -6.67 to 0.80, P = 0.12, I = 83.1 %] following supplementation with sumac powder.

CONCLUSION

This meta-analysis showed no significant effects on any glycemic indices following supplementation with sumac powder.

Address: Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran; Research Center for Environmental Determinants of Health (RCEDH), School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Student Research Committee, Lorestan University of Medical Sciences, Korramabad, Iran.; Department of Nutritional Sciences, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.; School of Nutrition, Chung Shan Medical University, Taichung City, Taiwan, ROC.; Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: [email protected].

DOI: 10.1016/j.ctim.2021.102766

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MeSH Terms: Blood Glucose, Dietary Supplements, Glycated Hemoglobin, Glycemic Index, Humans, Rhus