British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV.

Shayda A Swann, Angela Kaida, Valerie Nicholson, Jason Brophy, Amber R Campbell, Allison Carter, Chelsea Elwood, Tsion Gebremedhen, Rebecca Gormley, Elizabeth M King, Melanie Lee, Vonnie Lee, Evelyn J Maan, Patience Magagula, Sheila Nyman, Davi Pang, Neora Pick, Tetiana Povshedna, Jerilynn C Prior, Joel Singer, Shelly Tognazzini, Melanie C M Murray, Helene C F Cote

Journal: BMJ open 2021;11(8):e046558

PMID: 34362800

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Abstract

INTRODUCTION

Women living with HIV (WLWH) experience accelerated ageing and an increased risk of age-associated diseases earlier in life, compared with women without HIV. This is likely due to a combination of viral factors, gender differences, hormonal imbalance and psychosocial and structural conditions. This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.

METHODS AND ANALYSIS

The British Columbia hildren and Women: ntietroviral therapy and arkers of ging-anadian V omen's Sexual and Reproductive Health Cohort tudy (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. A subset of BCC3 participants will be past participants of CARMA, n≥1000 women and children living with and without HIV, 2008-2018 and/or CHIWOS, n=1422 WLWH, 2013-2018. Over two study visits, we will collect biological specimens for virus serologies, hormones and biological markers as well as administer a survey capturing demographic and sociostructural-behavioural factors. Sociodemographics, comorbidities, number and type of chronic/latent viral infections and hormonal irregularities will be compared between the two groups. Their association with biological markers and psychostructural and sociostructural factors will be investigated through multivariable regression and structural equation modelling. Retrospective longitudinal analyses will be conducted on data from past CARMA/CHIWOS participants. As BCC3 aims to follow participants as they age, this protocol will focus on the first study visits.

ETHICS AND DISSEMINATION

This study has been approved by the University of British Columbia Children's and Women's Research Ethics Board (H19-00896). Results will be shared in peer-reviewed journals, conferences and at community events as well as at www.hivhearme.ca and @HIV_HEAR_me. WLWH are involved in study design, survey creation, participant recruitment, data collection and knowledge translation. A Community Advisory Board will advise the research team throughout the study.

Address: Experimental Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; Epidemiology and Population Health, BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.; Division of Infectious Diseases, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; Oak Tree Clinic, BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; Faculty of Medicine, The Kirby Institute, Sydney, New South Wales, Australia.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; Obstetrics and Gynecology, BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.; Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.; Afro-Caribbean Positive Network of BC, Vancouver, British Columbia, Canada.; Bear Rock Consulting, Lone Butte, British Columbia, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; Division of Infectious Diseases, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.; Pathology and Laboratory Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada.; Centre for Menstrual Cycle and Ovulatory Research, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.; British Columbia Women's Hospital and Health Centre Women's Health Research Institute, Vancouver, British Columbia, Canada [email protected].; Pathology and Laboratory Medicine, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.

DOI: 10.1136/bmjopen-2020-046558

Link outs

Free resources

Full Text Sources:

Medical:

https://medlineplus.gov/hivinwomen.html

Miscellaneous:

https://assays.cancer.gov/CPTAC-68

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: British Columbia, Child, Cohort Studies, Female, HIV Infections, Healthy Aging, Humans, Retrospective Studies