Targeting interleukin-β by plant-derived natural products: Implications for the treatment of atherosclerotic cardiovascular disease.

Fatemeh Vahdat-Lasemi, Seyed Hamid Aghaee-Bakhtiari, Aida Tasbandi, Mahmoud Reza Jaafari, Amirhossein Sahebkar

Journal: Phytotherapy research : PTR 2021;35(10):5596-5622

PMID: 34390063

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Abstract

Inflammation is the main contributing factor to atheroma formation in atherosclerosis. Interleukin-1 beta (IL-1β) is an inflammatory mediator found in endothelial cells and resident leukocytes. Canakinumab is a selective monoclonal antibody against IL-1β which attenuates inflammation and concurrently precipitates fatal infections and sepsis. Natural products derived from medicinal plants, herbal remedy and functional foods are widely used nowadays. Experimental and clinical trial evidence supports that some natural products such as curcumin, resveratrol, and quercetin have potential effects on IL-1β suppression. In this review, we tried to document findings that used medicinal plants and plant-based natural products for treating atherosclerosis and its related diseases through the suppression of IL-1β.

Address: Department of Medical Biotechnology and Nanotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Bioinformatics Research Group, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Medicine, The University of Western Australia, Perth, Australia.

DOI: 10.1002/ptr.7194

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MeSH Terms: Antibodies, Monoclonal, Atherosclerosis, Biological Products, Cardiovascular Diseases, Endothelial Cells, Humans, Interleukin-1beta