Selenosteroids - promising hybrid compounds with pleiotropic biological activity: synthesis and biological aspects.

Izabella Jastrzebska, Pawel A Grzes, Katarzyna Niemirowicz-Laskowska, Halina Car

Journal: The Journal of steroid biochemistry and molecular biology 2021;213():105975

PMID: 34418527

Full Text on Elsevier Science View on PubMed

Abstract

It is established that steroid based agents are an example of compounds obtained from natural patterns and are of great importance due to their application in the prevention and treatment of diseases. Selenosteroids are hybrids formed by attaching Se-moiety to a steroid molecule. In these types of hybrids, selenium can be present as selenide or as a part of selenosemicarbazones, isoselenocyanates, selenourea, etc. Attaching a Se-moiety to a biologically active steroid might enhance the biological properties of both fragments. Available literature indicates that these kinds of hybrids demonstrate significant anticancer activity, which renders them interesting in terms of medical use. In this review, we present various methods of synthesis and demonstrate that seleno-steroid compounds are promising molecules for further pharmaceutical application.

Address: Faculty of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245, Białystok, Poland. Electronic address: [email protected].; Faculty of Chemistry, University of Białystok, ul. Ciołkowskiego 1K, 15-245, Białystok, Poland.; Department of Experimental Pharmacology, Medical University of Bialystok, ul. Szpitalna 37, 15-295, Białystok, Poland. Electronic address: [email protected].; Department of Experimental Pharmacology, Medical University of Bialystok, ul. Szpitalna 37, 15-295, Białystok, Poland.

DOI: 10.1016/j.jsbmb.2021.105975

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S0960...

MeSH Terms: Antineoplastic Agents, Hormonal, Cell Line, Tumor, Cell Survival, Chemistry Techniques, Synthetic, Cyanates, Humans, Inhibitory Concentration 50, Organoselenium Compounds, Selenium Compounds, Semicarbazones, Steroids, Structure-Activity Relationship, Urea