Modulation of immune response in Ebola virus disease.

Goutam Banerjee, Kamal Shokeen, Nilanjan Chakraborty, Saumya Agarwal, Arindam Mitra, Sachin Kumar, Pratik Banerjee

Journal: Current opinion in pharmacology 2021;60():158-167

PMID: 34425392

Full Text on Elsevier Science View on PubMed

Abstract

Ebola virus disease targets and destroys immune cells, including macrophages and dendritic cells, leading to impairment of host response. After infection, a combination of strategies including alteration and evasion of immune response culminating in a strong inflammatory response can lead to multi-organ failure and death in most infected patients. This review discusses immune response dynamics, mainly focusing on how Ebola manipulates innate and adaptive immune responses and strategizes to thwart host immune responses. We also discuss the challenges and prospects of developing therapeutics and vaccines against Ebola.

Address: Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.; Department of Microbiology, Adamas University, Kolkata, West Bengal, 700126, India.; Department of Microbiology, Adamas University, Kolkata, West Bengal, 700126, India. Electronic address: [email protected].; Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India. Electronic address: [email protected].; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address: [email protected].

DOI: 10.1016/j.coph.2021.07.004

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MeSH Terms: Ebolavirus, Hemorrhagic Fever, Ebola, Humans, Immunity, Innate, Macrophages