The multi-functional roles of forkhead box protein O in skin aging and diseases.

Kyoung Mi Moon, Min-Kyeong Lee, Taehyeok Hwang, Chun Whan Choi, Min Soo Kim, Hyeung-Rak Kim, Bonggi Lee

Journal: Redox biology 2021;46():102101

PMID: 34418600

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Abstract

Forkhead box, class O (FoxO) family members are multifunctional transcription factors that are involved in several metabolic processes, including energy metabolism, apoptosis, DNA repair, and oxidative stress. However, their roles in skin health have not been well-documented. Recent studies have indicated that FoxOs are important factors to control skin homeostasis and health. The activation or deactivation of some FoxO family members is closely related to melanogenesis, wound healing, acne, and melanoma. In this review, we have discussed the recent findings that demonstrate the relationship between FoxOs and skin health as well as the underlying mechanisms associated with their functions.

Address: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Republic of Korea.; Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea.; Natural Product Research Team, Biocenter, Gyeonggido Business and Science Accelerator, Gyeonggi-Do, Republic of Korea.; Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul, 02792, Republic of Korea.; Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea. Electronic address: [email protected].

DOI: 10.1016/j.redox.2021.102101

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https://medlineplus.gov/skinaging.html

MeSH Terms: Apoptosis, Forkhead Box Protein O1, Forkhead Transcription Factors, Oxidative Stress, Skin, Skin Aging