New monoterpenoids from the stigmas of Crocus sativus.

Qing-Wei Fang, Wen-Wei Fu, Jin-Ling Yang, Yue Lu, Jiang-Cheng Chen, Pei-Ying Wu, Xue Zhang, Hong-Xi Xu

Journal: Journal of natural medicines 2022;76(1):102-109

PMID: 34417964

Abstract

One new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins N-P (2-4), along with nine known compounds were isolated from the dried stigmas of Crocus sativus. The structures of new compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of 1, 2, and 3 were unambiguously assigned by the comparison of experimental and calculated ECD data. This is the first report of the isolation of 4 with the HMG moiety from the genus Crocus. Compounds 1 and 4 exhibited weak anti-inflammatory activities on inhibiting lipopolysaccharide (LPS)-induced NO production.

Address: School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai, 201203, People's Republic of China.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai, 201203, People's Republic of China. [email protected].; Saffron Div. of Shanghai Traditional Chinese Medicine Co., Ltd, Shanghai, 200002, People's Republic of China.; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Cai Lun Lu 1200, Shanghai, 201203, People's Republic of China. [email protected].; Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200002, People's Republic of China. [email protected].

DOI: 10.1007/s11418-021-01559-1

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https://dx.doi.org/10.1007/s11418-021-01559-1

MeSH Terms: Anti-Inflammatory Agents, Crocus, Flowers, Monoterpenes, Phytochemicals