Cardiac Resynchronization and Circulating Markers of Sarcoplasmic Reticulum Calcium Handling and Sudden Death Risk.

Ning Jiang, Anyu Zhou, Hafiz Imran, Guangbin Shi, Bahaa Kaseer, Vincent Siu, Antony F Chu, David M Donaldson, Malcolm M Kirk, Binu B Philips, Samuel C Dudley

Journal: JACC. Clinical electrophysiology 2021;7(9):1079-1083

PMID: 34454876

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Abstract

Cardiac resynchronization therapy (CRT) can improve heart function and decrease arrhythmic events. We tested whether CRT altered circulating markers of calcium handling and sudden death risk. Circulating cardiac sodium channel messenger RNA (mRNA) splicing variants indicate arrhythmic risk, and a reduction in sarco/endoplasmic reticulum calcium adenosine triphosphatase 2a (SERCA2a) is thought to diminish contractility in heart failure. CRT was associated with a decreased proportion of circulating, nonfunctional sodium channels and improved SERCA2a mRNA expression. Patients without CRT did not have improvement in the biomarkers. These changes might explain the lower arrhythmic risk and improved contractility associated with CRT.

Address: Lifespan Cardiovascular Institute, Brown University, Providence, Rhode Island, USA.; Department of Medicine, Brown University, Providence, Rhode Island, USA.; Cardiology Division, University of Toronto, Toronto, Ontario, Canada.; Department of Medicine, University of California at Irvine, Irvine, California, USA.; Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA. Electronic address: [email protected].

DOI: 10.1016/j.jacep.2021.07.003

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MeSH Terms: Biomarkers, Calcium, Cardiac Resynchronization Therapy, Death, Sudden, Humans, Sarcoplasmic Reticulum