Dynamic Changes in Human Milk Oligosaccharides in Chinese Population: A Systematic Review and Meta-Analysis.

Yalin Zhou, Han Sun, Kaifeng Li, Chengdong Zheng, Mengnan Ju, Ying Lyu, Runlong Zhao, Wenqing Wang, Wei Zhang, Yajun Xu, Shilong Jiang

Journal: Nutrients 2021;13(9):2912

PMID: 34578788

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Abstract

The aim of this systematic review was to summarize concentrations of human milk oligosaccharides (HMOs) in the Chinese population. We searched articles originally published in both Chinese and English. When compiling data, lactation was categorized into five stages. We found that 6'-sialyllactose, lacto--tetraose, and lacto--neotetraose decreased over lactation. Conversely, 3'-fucosyllactose increased over lactation. Our study represents the first systematic review to summarize HMO concentrations in Chinese population. Our findings not only provide data on HMO profiles in Chinese population but suggest future directions in the study of the metabolism of HMOs.

Address: Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Xueyuan Road 38, Haidian, Beijing 100083, China.; PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Xueyuan Road 38, Haidian, Beijing 100083, China.; Innovation Center, Nutrition and Metabolism Research Division, Heilongjiang Feihe Dairy Co., Ltd., C-16, 10A Jiuxianqiao Rd., Chaoyang, Beijing 100015, China.; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Xueyuan Road 38, Haidian, Beijing 100083, China.

DOI: 10.3390/nu13092912

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MeSH Terms: Breast Feeding, China, Female, Fucose, Humans, Lactation, Lactose, Milk, Human, Oligosaccharides, Sialic Acids