Evaluation of Apigenin Inhibiting Lactate Dehydrogenase Activity Based on CdTe Quantum Dots Fluorescence.

Xiangling Ren, Meijia Liu, Ming Tang, Longfei Tan, Changhui Fu, Qiong Wu, Hongbo Li, Yi Chen, Lufeng Chen, Xianwei Meng

Journal: Journal of biomedical nanotechnology 2021;17(9):1806-1811

PMID: 34688325

Abstract

Lactate dehydrogenase (LDH) is one of key enzymes in glucose metabolism pathway, which plays a critical role in cell metabolism. Inhibition of LDH can inhibit glycolysis process, thereby inhibiting the occurrence and development of tumor cells. Two kinds of LDH inhibitors, apigenin and emodin, were obtained by testing the IC of several natural products in LDH enzyme reaction. The IC of apigenin was about 1/3 of LDH inhibitor sodium oxalate. A new method to evaluate the performance of LDH inhibitors based on CdTe QDs was established at the same time, which provides a new idea for research on LDH enzyme inhibitors.

Address: Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing, 100081, China.; Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.; Department of Radiation Oncology, First Clinical Medical School and First Hospital of Shanxi Medical University, Taiyiuan, 030001, China.

DOI: 10.1166/jbn.2021.3158

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MeSH Terms: Apigenin, Cadmium Compounds, Fluorescence, L-Lactate Dehydrogenase, Quantum Dots, Tellurium