Metabolic regulation of the bone marrow microenvironment in leukemia.

Binyan Xu, Rong Hu, Zhao Liang, Tong Chen, Jianyu Chen, Yuxing Hu, Yirong Jiang, Yuhua Li

Journal: Blood reviews 2021;48():100786

PMID: 33353770

Full Text on Elsevier Science View on PubMed

Abstract

Most leukemia patients experience little benefit from immunotherapy, in part due to the immunosuppressive bone marrow microenvironment. Various metabolic mechanisms orchestrate the behaviors of immune cells and leukemia cells in the bone marrow microenvironment. Furthermore, leukemia cells regulate the bone marrow microenvironment through metabolism to generate an adequate supply of energy and to escape antitumor immune surveillance. Thus, the targeting of the interaction between leukemia cells and the bone marrow microenvironment provides a new therapeutic avenue. In this review, we describe the concept of the bone marrow microenvironment and several important metabolic processes of leukemia cells within the bone marrow microenvironment, including carbohydrate, lipid, and amino acid metabolism. In addition, we discuss how these metabolic pathways regulate antitumor immunity and reveal potential therapeutic targets.

Address: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, PR China.; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, PR China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, PR China.; Department of Hematology, Affiliated Dongguan People's Hospital, Southern Medical University, Dongguan, Guangdong 523059, PR China. Electronic address: [email protected].; Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, PR China; Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), 510005 Guangzhou, PR China. Electronic address: [email protected].

DOI: 10.1016/j.blre.2020.100786

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MeSH Terms: Bone Marrow, Disease Management, Disease Susceptibility, Energy Metabolism, Humans, Immunologic Surveillance, Leukemia, Metabolic Networks and Pathways, Tumor Microenvironment