Adenosine-to-inosine RNA editing in neurological development and disease.

Yuxi Yang, Shunpei Okada, Masayuki Sakurai

Journal: RNA biology 2021;18(7):999-1013

PMID: 33393416

Abstract

["Adenosine-to-inosine (A-to-I) editing is one of the most prevalent post-transcriptional RNA modifications in metazoan. This reaction is catalysed by enzymes called adenosine deaminases acting on RNA (ADARs). RNA editing is involved in the regulation of protein function and gene expression. The numerous A-to-I editing sites have been identified in both coding and non-coding RNA transcripts. These editing sites are also found in various genes expressed in the central nervous system (CNS) and play an important role in neurological development and brain function. Aberrant regulation of RNA editing has been associated with the pathogenesis of neurological and psychiatric disorders, suggesting the physiological significance of RNA editing in the CNS. In this review, we discuss the current knowledge of editing on neurological disease and development."]

Address: Research Institute for Biomedical Sciences, Tokyo University of Science, Noda-shi, Chiba, Japan.

DOI: 10.1080/15476286.2020.1867797

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MeSH Terms: Adenosine, Amyotrophic Lateral Sclerosis, Astrocytoma, Bipolar Disorder, Central Nervous System Neoplasms, Epilepsy, Humans, Inosine, Kv1.1 Potassium Channel, MicroRNAs, RNA Editing, Receptor, Serotonin, 5-HT2C, Receptors, AMPA, Schizophrenia, Spasms, Infantile