Multiple interactions between melatonin and non-coding RNAs in cancer biology.

Masomeh Maleki, Nafiseh Khelghati, Forough Alemi, Simin Younesi, Zatollah Asemi, Rozita Abolhasan, Mahtab Bazdar, Hossein Samadi-Kafil, Bahman Yousefi

Journal: Chemical biology & drug design 2021;98(3):323-340

PMID: 33905613

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Abstract

The melatonin hormone secreted by the pineal gland is involved in physiological functions such as growth and maturation, circadian cycles, and biological activities including antioxidants, anti-tumor, and anti-ischemia. Melatonin not only interacts with proteins but also has functional effects on regulatory RNAs such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). In this study, we overview various physiological and pathological conditions affecting melatonin through lncRNA and miRNA. The information compiled herein will serve as a solid foundation to formulate ideas for future mechanistic studies on melatonin. It will also provide a chance to more clarify the emerging functions of the non-coding transcriptome.

Address: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.; Department of Clinical Biochemistry, Urmia University of Medical Sciences, Urmia, Iran.; School of Health and Biomedical Sciences, RMIT University, Melbourne, Vic., Australia.; School of Health and Biomedical Sciences, RMIT University, Melbourne, Vic., Australia.; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.; Stem Cell and Regenerative Medicine Institute (SCARM), Tabriz University of Medical Sciences, Tabriz, Iran.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

DOI: 10.1111/cbdd.13849

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MeSH Terms: Apoptosis, Cell Cycle Checkpoints, Cyclin-Dependent Kinases, Cyclins, Gene Expression Regulation, Neoplastic, Humans, Melatonin, MicroRNAs, Neoplasms, RNA, Long Noncoding