Iron metabolism: pathophysiology and pharmacology.

Karolin Roemhild, Finn von Maltzahn, Ralf Weiskirchen, Ruth Knüchel, Saskia von Stillfried, Twan Lammers

Journal: Trends in pharmacological sciences 2021;42(8):640-656

PMID: 34090703

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Abstract

["Iron is essential in many physiological processes, including DNA metabolism, oxygen transport, and cellular energy generation. Deregulated iron metabolism, which results in iron overload or iron deficiency, is observed in many different diseases. We here summarize recent progress in the pathophysiology and pharmacology of iron-overload diseases, such as hereditary hemochromatosis, as well as iron-deficiency disorders, which are typically associated with anemia. The role of iron in immunity and the connection between iron and cancer are also addressed. We finally summarize and discuss the current (pre-) clinical landscape of pharmacotherapies targeting key players involved in iron metabolism.",{"copyright":"Copyright \u00a9 2021 Elsevier Ltd. All rights reserved."}]

Address: Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH University Hospital Aachen, Aachen 52074, Germany; Institute of Pathology, Medical Faculty, RWTH University Hospital Aachen, Aachen 52074, Germany.; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH University Hospital Aachen, Aachen 52074, Germany.; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH University Hospital Aachen, Aachen 52074, Germany.; Institute of Pathology, Medical Faculty, RWTH University Hospital Aachen, Aachen 52074, Germany.; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, RWTH University Hospital Aachen, Aachen 52074, Germany. Electronic address: [email protected].

DOI: 10.1016/j.tips.2021.05.001

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MeSH Terms: Hemochromatosis, Humans, Iron, Iron Overload, Neoplasms