Diterpenoids from the genus Euphorbia: Structure and biological activity (2013-2019).

Yang Xu, Peiyu Tang, Man Zhu, Yali Wang, Dejuan Sun, Hua Li, Lixia Chen

Journal: Phytochemistry 2021;190():112846

PMID: 34229224

Full Text on Elsevier Science View on PubMed

Abstract

Euphorbiaceae is one of the largest families of higher plants, including 7500 species, and many of them are used as medicines in China. From 2013 to 2019, a total of 455 previously undescribed diterpenoids were isolated from 53 species of Euphorbia, and some skeleton types were first discovered from the genus Euphorbia. Most of the diterpenoids isolated from Euphorbia spp. have been tested for their biological activity, and some of them were first reported for Euphorbia diterpenoids in recent years, such as neuroprotection, antimalarial activity and inhibition of osteoclast formation. In this review, we summarize all the isolated diterpenoids from the genus Euphorbia according to their skeleton types, classify all these diterpenoids into 26 normal classes and 37 novel skeleton types, and summarize their biological activity.

Address: Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: [email protected].; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China; School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. Electronic address: [email protected].; Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China. Electronic address: [email protected].

DOI: 10.1016/j.phytochem.2021.112846

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MeSH Terms: China, Diterpenes, Euphorbia, Molecular Structure