GPR3 sets brown fat on fire.

Miroslav Balaz, Christian Wolfrum

Journal: Cell metabolism 2022;33(7):1271-1273

PMID: 34233169

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Abstract

Activation of thermogenic adipocytes, a process canonically driven by norepinephrine through β-adrenergic receptors, presents an appealing therapeutic approach to combat obesity. Recent work by Sveidahl Johansen et al., 2021 published in Cell has identified a noncanonical mechanism of brown adipocyte activation, in which lipolysis transcriptionally drives the constitutive activation of the G protein-coupled receptor, GPR3, to induce thermogenesis.

Address: Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.; Institute of Food, Nutrition and Health, ETH Zürich, Schwerzenbach, Switzerland. Electronic address: [email protected].

DOI: 10.1016/j.cmet.2021.06.003

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MeSH Terms: Adipocytes, Brown, Adipose Tissue, Brown, Humans, Lipolysis, Obesity, Receptors, G-Protein-Coupled, Thermogenesis