The Impact of Uric Acid and Hyperuricemia on Cardiovascular and Renal Systems.

Davide Agnoletti, Arrigo F G Cicero, Claudio Borghi

Journal: Cardiology clinics 2021;39(3):365-376

PMID: 34247750

Full Text on Elsevier Science View on PubMed

Abstract

The description of gout dates back almost 5000 years, and scientific interest in uric acid increased when it was found to be involved in the pathogenesis of gout. Since then, many basic and clinical studies have assessed the implications of uric acid for the oxidative system, inflammation, and cardiovascular and renal outcomes. Uric acid-lowering therapy failed to improve clinical hard outcomes in asymptomatic hyperuricemia, and it is retained in symptomatic hyperuricemia. Dietary and lifestyle modifications are critical to manage hyperuricemia. More studies are warranted to investigate the role of uric acid-lowering drugs on cardiovascular outcomes.

Address: Internal Medicine Department, IRCCS Sacro Cuore Hospital, Viale Luigi Rizzardi 4, Negrar di Valpolicella (VR) 37024, Italy.; Medical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, Bologna 40138, Italy.; Medical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, Bologna 40138, Italy. Electronic address: [email protected].

DOI: 10.1016/j.ccl.2021.04.009

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MeSH Terms: Gout, Humans, Hyperuricemia, Kidney, Radiopharmaceuticals, Uric Acid