Peptides for disrupting and degrading amyloids.

Chu-Qiao Liang, Yan-Mei Li

Journal: Current opinion in chemical biology 2022;64():124-130

PMID: 34274561

Full Text on Elsevier Science View on PubMed

Abstract

Amyloid proteins can aggregate into insoluble fibrils and form amyloid deposits in the human brain, which is the hallmark of many neurodegenerative diseases. Promising strategies toward pathological amyloid proteins and deposition include investigating inhibitors that can disrupt amyloid aggregation or induce misfolding protein degradation. In this review, recent progress of peptide-based inhibitors, including amyloid sequence-derived inhibitors, designed peptides, and peptide mimics, is highlighted. Based on the increased understanding of peptide design and precise amyloid structures, these peptides exhibit advanced inhibitory activities against fibrous aggregation as well as enhanced druggability.

Address: Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, PR China.; Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, PR China; Beijing Institute for Brain Disorders, Beijing, 100069, PR China; Center for Synthetic and System Biology, Tsinghua University, Beijing, 100084, PR China. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2021.05.011

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MeSH Terms: Amyloid, Amyloid beta-Peptides, Humans, Neurodegenerative Diseases, Peptides