Proportions of circulating transitional B cells associate with MRI activity in interferon beta-treated multiple sclerosis patients.

Max Mimpen, Jan Damoiseaux, William van Doorn, Linda Rolf, Anne-Hilde Muris, Raymond Hupperts, Marvin M van Luijn, Oliver Gerlach, Joost Smolders

Journal: Journal of neuroimmunology 2021;358():577664

PMID: 34280843

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Abstract

B-cells contribute to MS pathogenesis. The association of circulating B-cell phenotypes with combined unique active lesions (CUA) on MRI at 48 weeks follow-up was investigated in 50 interferon beta-treated MS patients. Transitional B-cell proportions were lower in participants with CUA at week 0 and 48 [p = 0.004, p = 0.002]. A decrease in circulating anti-EBNA-1 IgG levels between week 0 and 48 associated with absence of CUA [p = 0.047], but not with B-cell profiles. In a multi-factor model for CUA-risk, transitional B-cell proportions contributed independent from NK/T-cell ratio, change in anti-EBNA-1 IgG, and vitamin D supplementation. Transitional B-cells may predict treatment response in MS.

Address: School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.; Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: [email protected].; Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands; CARIM School for vascular diseases, Maastricht, the Netherlands.; School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; Department of Neurology, Zuyderland Medical Center, Sittard-Geleen, the Netherlands.; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Neurology, MS Center ErasMS, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Neuroimmunology, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.

DOI: 10.1016/j.jneuroim.2021.577664

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MeSH Terms: Cholecalciferol, Humans, Immunologic Factors, Interferon-beta, Magnetic Resonance Imaging, Multiple Sclerosis, Precursor Cells, B-Lymphoid