Effects of body weight regain on leptin levels: A systematic review and meta-analysis.

Najme Rostami Rayeni, Hadi Abdollahzad, Pooya Alibakhshi, Mojgan Morvaridzadeh, Hafez Heydari, Afsaneh Dehnad, Masoud Khorshidi, Azimeh Izadi, Farzad Shidfar, M Dulce Estêvão, Amirhosein Omidi, Javad Heshmati

Journal: Cytokine 2022;148():155647

PMID: 34344588

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

There are different changes observed before and after diet therapy, and also after weight regain. However, there is not sufficient information regarding weight regain and hormonal changes.

PURPOSE

The purpose of this study was to review the connection between weight regain and leptin concentration levels.

METHODS

MEDLINE, SCOPUS, Web of Science, and the Cochrane Library were searched for interventional articles published from January 1, 1980, to June 30, 2020. Randomized clinical trials with parallel or cross over design assessing leptin concentrations at the baseline and at the end of study were reviewed. Two independent reviewers extracted data related to study design, year of publication, country, age, gender, body mass index (BMI), duration of the following up period and mean ± SD of other intended variables.

RESULTS

Four articles were included, published between 2004 and 2016. Three of them were conducted in the US and one of them in Netherland. Sample size of the studies ranged between 25 and 148 participants. The range of following up period was from13 to 48 weeks. The age range of participants was from 34 to 44 years. Our analysis shows that weight regain could reduce leptin levels, but this change is not statistically significant.

CONCLUSION

This review suggests that weight regain may induce a non-significant reduction in leptin level. However, the limited number and great heterogeneity between the included studies may affect the presented results and there are still need to well-designed, large population studies to determine the relationship between weight regain and leptin levels.

Address: Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.; Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.; Department of English Language, School of Health Management and Information Sciences, Center for Educational Research in Medical Sciences (CERMS), Iran University of Medical Sciences, Iran. Electronic address: [email protected].; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Iran Football Medical Assessment and Rehabilitation Center (IFMARC), Tehran, Iran; Department of Biochemistry and Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Universidade do Algarve, Escola Superior de Saúde, Campus de Gambelas, Faro, Portugal. Electronic address: [email protected].; Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: [email protected].

DOI: 10.1016/j.cyto.2021.155647

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MeSH Terms: Adult, Humans, Leptin, Publication Bias, Risk, Weight Gain