Epstein-Barr Virus-positive Intestinal Diffuse Large B-cell Lymphoma in a Japanese Patient with Celiac Disease: First Reported Case and a Literature Review.

Hideto Sakisaka, Morishige Takeshita, Fumihito Hirai, Yasushi Takamatsu, Sadahiro Funakoshi, Koichi Abe, Nobuaki Kuno, Satoshi Matsuoka, Taro Tanabe, Hideki Ishibashi, Tomomi Yamashima, Hideki Yasuda, Hiroki Matsuoka, Mamoru Shibata, Ryohei Nomaru, Maki Goto, So Imakiire

Journal: Internal medicine (Tokyo, Japan) 2022;61(3):329-334

PMID: 34334570

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Abstract

A 60-year-old Japanese woman was diagnosed with celiac disease (CeD) and treated with a gluten-free diet. For five years, she had a good clinical course. However, she complained of inappetence and nausea. Colonoscopy revealed ulcerative tumors in the terminal ileum. A histological examination of biopsy specimens from the ulcerative tumor showed diffuse infiltration of large atypical lymphocytes. Immunohistologically, the atypical lymphoid cells were positive for cluster of differentiation (CD) 10 and CD20. Many Epstein-Barr virus-encoded small RNA (EBER)-positive atypical lymphocytes were detected by in situ hybridization. This represents the first reported case of Epstein-Barr virus-positive intestinal diffuse large B-cell lymphoma complicated with CeD.

Address: Department of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.; Division of Medical Oncology, Hematology and Infectious Diseases Faculty of Medicine, Fukuoka University, Japan.; Department of Pathology, Fukuoka University Faculty of Medicine, Japan.

DOI: 10.2169/internalmedicine.7876-21

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MeSH Terms: Celiac Disease, Epstein-Barr Virus Infections, Female, Herpesvirus 4, Human, Humans, Japan, Lymphoma, Large B-Cell, Diffuse, Middle Aged