Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke.

Yan Han, Ying Chen, Qian Zhang, Bo-Wen Liu, Li Yang, You-Hua Xu, Yong-Hua Zhao

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2021;90():153652

PMID: 34362631

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Ischemic stroke is a common cerebrovascular disease. Due to sudden interruption of blood flow by arterial thrombus, amounts of neurons in ischemic central and penumbral regions occur necrosis and apoptosis resulting in serious injury of neurological function. Chinese medicines have a great advantage in ischemic stroke treatment and recovery, especially Angelica sinensis.

PURPOSE

There are a large number of studies reported that Angelica injection and A. sinensis active compounds. We systematically reviewed the effects and mechanisms of A. sinensis in recent years according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements, and excavated its therapeutic potentiality for exploring more effective and safe compounds for ischemic stroke precision treatment.

RESULTS

A. sinensis extracts and active compounds, such as Z-ligustilide, 3-n-Butylphthalide, and ferulic acid have significant effects of anti-inflammation, anti-oxidative stress, angiogenesis, neurogenesis, anti-platelet aggregation, anti-atherosclerosis, protection of vessels, which contributes to improvement of neurological function on ischemic stroke.

CONCLUSION

A. sinensis is a key agent for ischemic stroke treatment, and worth deeply excavating its therapeutic potentiality with the aid of pharmacological network, computer-aided drug design, artificial intelligence, big data and multi-scale modelling techniques.

Address: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa SRA 999078, Macao, China.; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu, China.; Department of Neurology, Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen Hospital of Shanghai University of Traditional Chinese Medicine, Shenzhen 518001, Guangdong, China.; State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, , Taipa SRA 999078, Macao, China.

DOI: 10.1016/j.phymed.2021.153652

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MeSH Terms: Angelica sinensis, Brain Ischemia, Drugs, Chinese Herbal, Humans, Ischemic Stroke