Curcumin as a great contributor for the treatment and mitigation of colorectal cancer.

Chenmala Karthika, Balaji Hari, Vignesh Mano, Arun Radhakrishnan, S K Janani, Rokeya Akter, Deepak Kaushik, Md Habibur Rahman

Journal: Experimental gerontology 2021;152():111438

PMID: 34098006

Full Text on Elsevier Science View on PubMed

Abstract

Cancer is one of the life-taking diseases worldwide and among cancer-related death; colorectal cancer is the third most. Though conventional methods of treatment are available, multidrug resistance and side effects are predominant. Physicians and scientists are working side by side to develop an effective medicament, which is safe and cost-effective. However, most failures are obtained when focused on the clinical perspective. This review mainly brings out the correlation between the curcumin and its use for the mitigation of colorectal cancer, the use of curcumin as a chemotherapeutic agent, chemosensitizer, and in a combination and synergistic approach. The pharmacokinetics and pharmacodynamics properties of curcumin and its formulation approach helps in giving an idea to develop new approaches for the treatment of colorectal cancer using curcumin.

Address: Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India. Electronic address: [email protected].; TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS Academy of Higher Education & Research, Ooty-643001, The Nilgiris, Tamil Nadu, India.; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Nilgiris, Tamil Nadu, India.; Department of Pharmacy, Jagannath University, Sadarghat, Dhaka 1100, Bangladesh.; Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India.; Department of Pharmacy, Southeast University, Banani, Dhaka 1213, Bangladesh; Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University,Wonju 26426, Gangwon-do, Korea.. Electronic address: [email protected].

DOI: 10.1016/j.exger.2021.111438

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MeSH Terms: Antineoplastic Agents, Colorectal Neoplasms, Curcumin, Drug Resistance, Multiple, Humans