From Bench to Biomolecular Simulation: Phospholipid Modulation of Potassium Channels.

Tanadet Pipatpolkai, Daniel Quetschlich, Phillip J Stansfeld

Journal: Journal of molecular biology 2021;433(17):167105

PMID: 34139216

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Abstract

Potassium (K) ion channels are crucial in numerous cellular processes as they hyperpolarise a cell through K conductance, returning a cell to its resting potential. K channel mutations result in multiple clinical complications such as arrhythmia, neonatal diabetes and migraines. Since 1995, the regulation of K channels by phospholipids has been heavily studied using a range of interdisciplinary methods such as cellular electrophysiology, structural biology and computational modelling. As a result, K channels are model proteins for the analysis of protein-lipid interactions. In this review, we will focus on the roles of lipids in the regulation of K channels, and how atomic-level structures, along with experimental techniques and molecular simulations, have helped guide our understanding of the importance of phospholipid interactions.

Address: Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK; Department of Physiology Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK; OXION Initiative in Ion Channels and Disease, University of Oxford, Oxford OX1 3PT, UK.; Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK; Department of Chemistry, South Parks Road, Oxford OX1 3QZ, UK.; School of Life Sciences & Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. Electronic address: [email protected].

DOI: 10.1016/j.jmb.2021.167105

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Full Text Sources:

Medical:

https://medlineplus.gov/potassium.html

Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Humans, Membrane Lipids, Phospholipids, Potassium, Potassium Channels