Use of erythropoietin in ophthalmology: a review.

Sepehr Feizi, Mohammadhasan Alemzadeh-Ansari, Farid Karimian, Hamed Esfandiari

Journal: Survey of ophthalmology 2022;67(2):427-439

PMID: 34157346

Full Text on Elsevier Science View on PubMed

Abstract

Erythropoietin (EPO) is a glycoprotein hormone that regulates hematopoiesis in the human body. The presence of EPO and its receptors in different tissues indicates that this hormone has extramedullary effects in other tissues, including the eye. We focus on the biological roles of this hormone in the development and normal physiologic functions of the eye. Furthermore, we explore the role of EPO in the management of different ocular diseases - including diabetic retinopathy, retinopathy of prematurity, inherited retinal degeneration, branch and central retinal vein occlusion, retinal detachment, traumatic optic neuropathy, optic neuritis, methanol optic neuropathy, nonarteritic anterior ischemic optic neuropathy, glaucoma, and scleral necrosis.

Address: Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: [email protected].; Ophthalmic Research Center, Department of Ophthalmology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.

DOI: 10.1016/j.survophthal.2021.06.002

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MeSH Terms: Diabetic Retinopathy, Erythropoietin, Eye Diseases, Humans, Ophthalmology, Optic Neuropathy, Ischemic, Retinal Vein Occlusion