The Role of Chemokines in Cardiovascular Diseases and the Therapeutic Effect of Curcumin on CXCL8 and CCL2 as Pathological Chemokines in Atherosclerosis.

Mahdiyeh Hedayati-Moghadam, Sara Hosseinian, Maryam Paseban, Arezoo Gowhari Shabgah, Jamshid Gholizadeh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar

Journal: Advances in experimental medicine and biology 2022;1328():155-170

PMID: 34981477

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Abstract

Curcumin, as a vegetative flavonoid, has a protective and therapeutic role in various adverse states such as oxidative stress and inflammation. Remedial properties of this component have been reported in the different chronic diseases including cancers (myeloma, pancreatic, breast, colorectal), vitiligo, psoriasis, neuropathic pains, inflammatory disorders (osteoarthritis, uveitis, ulcerative colitis, Alzheimer), cardiovascular conditions, and diabetes.Cardiovascular disorders include atherosclerosis and various manifestations of atherosclerosis such as stroke, and myocardial infarction (MI) is the leading cause of mortality globally. Studies have shown varying expressions of inflammatory and non-inflammatory chemokines and chemokine receptors in cardiovascular disease, which have been highlighted first in this review. The alteration in chemokines secretion and chemokine receptors has an essential role in the pathophysiology of cardiovascular disease. Chemokines as cytokines with low molecular weight (8-12 kDa) mediate white blood cell (WBC) chemotactic reactions, vascular cell migration, and proliferation that induce endothelial dysfunction, atherogenesis, and cardiac hypertrophy.Several studies reported that curcumin could be advantageous in the attenuation of cardiovascular diseases via anti-inflammatory effects and redress of chemokine secretion and chemokine receptors. We present these studies with a focus on two chemokines: CXCL8 (IL-8) and CCL2 (chemoattractant protein 1 or MCP-1). Future research will further elucidate the precise potential of curcumin on chemokines in the adjustment of cardiovascular system activity or curcumin chemokine-based therapies.

Address: Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.; Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Natural Products & Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.; School of Medicine, Bam University of Medical Sciences, Bam, Iran.; Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Tehran, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. [email protected].

DOI: 10.1007/978-3-030-73234-9_11