The Use of Thiazide Diuretics for the Treatment of Hypertension in Patients With Advanced Chronic Kidney Disease.

Ngoc-Yen T Pham, Jonathan G Owen, Namita Singh, Saeed Kamran Shaffi

Journal: Cardiology in review 2023;31(2):99-107

PMID: 34224450

Abstract

The use of thiazide diuretics for the treatment of hypertension in patients with advance chronic kidney disease. Thiazides have been recommended as the first-line for the treatment of hypertension, yet their use has been discouraged in advanced chronic kidney disease (CKD), as they are suggested to be ineffective in advanced CKD. Recent data suggest that thiazide diuretics may be beneficial blood pressure control in addition to natriuresis in existing CKD. This review discusses the commercially available thiazides with a focus on thiazide pharmacology, most common adverse effects, clinical uses of thiazide diuretic, and the evidence for efficacy of thiazide use in advanced CKD.

Address: From the University of New Mexico Hospitals, Albuquerque, NM.; University of New Mexico Health Sciences Center, Albuquerque, NM.

DOI: 10.1097/CRD.0000000000000404

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MeSH Terms: Humans, Sodium Chloride Symporter Inhibitors, Antihypertensive Agents, Hypertension, Thiazides, Renal Insufficiency, Chronic